Diosmin has venous action (reduces the extensibility of veins, increases the tone of veins (dose-dependent effect), reduces venous stasis), improves trenbolone acetate powder lymphatic drainage (increases the tone and frequency sokrasheniya lymph capillaries, increasing trenbolone acetate 100mg their functional density reduces the lymphatic pressure), improves microcirculation ( increases the resistance of capillaries (the dose-dependent effect), reduces their permeability), reduces adhesion of leukocytes to the venous wall and migrate into paravenoznye tissue and improves the diffusion of oxygen into the skin tissue perfusion, anti-inflammatory action. Enhances vasoconstrictive effect of epinephrine, norepinephrine, serotonin, blocks the production of free radicals, prostaglandins and thromboxane. Trenbolone acetate 100mg Following oral administration drug is rapidly absorbed from the gastrointestinal tract and determined in plasma 2 h. Maximum plasma concentration is achieved in 5 hours after ingestion. It accumulates and is evenly distributed in all layers of the wall of the vena cava and subcutaneous veins of the lower extremities, to a lesser extent – in the kidneys, liver, lungs and other organs. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum of 9 hour after administration and is maintained for 96 hours. Diosmin is derived from 79% of the urine, the feces – 11%, the bile – 2.4%.
varicose veins, chronic lymph-venous insufficiency of the lower limbs; aggravation of hemorrhoids; microcirculation disorders.
: Hypersensitivity to the drug, children (under 18 years).
Use during pregnancy and breastfeeding period
is trenbolone acetate powder still in clinical practice have been no reports of any side effects when using the drug in pregnant women. In experimental studies, there was no evidence of teratogenic effects on the fetus. During breast-feeding is not recommended taking the drug, as there are no data on the penetration of the drug in breast milk.
Dosing and Administration
In varicose veins, and in the early stages of chronic lymph-venous insufficiency (heavy legs) appoint 1 tablet per day in the morning before breakfast for 2 months, in severe forms of chronic lymph-venous insufficiency (edema, pain , convulsions, etc.) – the treatment is continued for 3-4 months, in the presence of trophic changes and ulcers prolong treatment up to 6 months or more. The course is repeated in 2-3 months.
In acute hemorrhoids prescribe the drug for 2-3 tablets a day with meals for 7 days, followed by, if necessary, can be extended by 1 tablet 1 time a day for 1-2 months.
In the treatment of chronic lymph-venous insufficiency during the II and III trimester of pregnancy appoint 1 tablet 1 time a day and canceled 2-3 weeks before delivery. If you missed one or more steps, continue to use the drug in normal dosage.
In rare cases, the part of the gastrointestinal tract – dyspeptic disorders of the central nervous system – headache.
Symptoms of overdose are not described.
Interaction with other drugs
clinically significant interaction effects with other drugs has not been described.
hemorrhoids exacerbation treatment is carried out in trenbolone acetate powder combination with other drugs, in the absence of rapid clinical effect needs further study and adjust the therapy.
There is evidence of potential efficacy in the treatment of placental insufficiency, for the prevention of bleeding arising from the use of intrauterine devices and during phlebectomy .