trenbolone acetate cycle

Nonsteroidal anti-inflammatory drug; has anti-inflammatory, analgesic and antipyretic effects associated with inhibition of cyclooxygenase 1 (TSOG1) and cyclooxygenase 2 (TSOG2) regulating the synthesis of prostaglandins. Shows uricosuric effect. Pharmacokinetics: At intake absorption – high; bioavailability – 85-90%, reduced by chronic administration. The time to maximum concentration (TCmax) – 1-2 hours Connection to plasma proteins -. 95%.

It is metabolized in the liver with the formation of two major metabolites. The half-life (T1 / 2) -. 18-24 hours excreted by the kidneys 70% (5% unchanged), the gastrointestinal tract – 30% in the form of metabolites in significant amounts excreted in breast milk.

Indications for use:

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, gout, psoriatic arthritis, ankylosing spondylitis (ankylosing spondylitis), osteoarthritis.

Pain: bursitis, tenosynovitis, arthralgia, myalgia, neuralgia, toothache and headache (including migraine), pain, tuberculosis, pain with injuries, burns.

It is intended for symptomatic therapy reduce pain and inflammation at the time of use, does not affect the progression of the disease.

 

Contraindications:

Hypersensitivity; complete or incomplete combination of bronchial asthma, recurrent nasal polyposis, and paranasal sinuses and intolerance of aspirin or other nonsteroidal anti-inflammatory drugs (including history); erosive and ulcerative lesions of the gastrointestinal tract in the acute stage (peptic ulcer and 12 duodenal ulcer, ulcerative colitis, peptic ulcer), bone marrow depression, decompensated chronic heart failure, or pulmonary heart disease, severe hepatic and / or renal insufficiency ( creatinine clearance less than 30 ml / min), the period after coronary artery bypass surgery; progressive kidney disease, active liver disease, confirmed by hyperkalemia, pregnancy (III trimester), active gastrointestinal bleeding, inflammatory bowel disease, children under 12 years.

 

Carefully:

Hyperbilirubinemia, bronchial asthma, chronic heart failure, edema, hypertension, hemophilia, anticoagulation, liver failure, chronic renal failure, hearing loss, the pathology of the vestibular apparatus, blood diseases, diabetes mellitus, systemic lupus erythematosus, polymyalgia rheumatica, temporal arteritis, ulcerative disease gastrointestinal tract disease, ischemic heart disease, cerebrovascular trenbolone acetate cycle disease, dyslipidemia / hyperlipidemia, peripheral arterial disease, smoking, creatinine clearance less than 60 mL / min, ulcerative lesions of the gastrointestinal tract in the history of the presence of Helicobacter infection pylori, advanced age, long the use of non-steroidal anti-inflammatory drugs, alcoholism, severe somatic diseases, simultaneous reception of oral corticosteroids (including prednisone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective inhibitors of reverse serotonin (including citalopram, fluoxetine, paroxetine, sertraline), I-II trimester of pregnancy, lactation.

 

Dosage and administration:

 

Inside, adults 150mg during or after meals 3-4 times a day. Children between 12 to 75 mg four times a day. The duration of therapy is determined by the severity of the condition.

Side effects:

From the digestive system: dyspepsia, NSAID-gastropathy, abdominal pain, nausea, vomiting, heartburn, diarrhea, or constipation; long-term use at high doses – ulceration of the mucosa of the gastrointestinal tract, aphthous stomatitis, glossitis, erosive esophagitis, bleeding trenbolone acetate cycle (gastrointestinal, gingival, hemorrhoids), abnormal liver function.

Cardio-vascular system: increased blood pressure, tachycardia.

From the nervous system: headache, dizziness, somnolence, depression, agitation.

From the senses: hearing loss, tinnitus.

From the side of hematopoiesis: agranulocytosis, leukopenia, anemia, thrombocytopenia.

Allergic reactions: skin rash, pruritus, urticaria, bronchospasm, edema syndrome, angioedema.

Other: increased sweating, uterine bleeding.

 

Overdose:

Symptoms: cyanosis of the fingertips, lips, body skin, dizziness, headache, increased or decreased blood pressure, hyperventilation, dizziness, children – myoclonic seizures, nausea, vomiting, abdominal pain, hemorrhage, liver and kidney function .

 

Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy aimed at maintaining vital functions. Forced diuresis and hemodialysis ineffective.

Interaction with other drugs:

 

Enhances the effect of anticoagulants, antiplatelet agents, fibrinolytic agents, the side effects of glucocorticoids and mineralocorticoids, estrogens, morphine, p-aminosalicylic acid, penicillin, hypoglycemic effect of sulfonylureas.

It reduces the urikozuricheskih, antihypertensive drugs and diuretics.

Increases concentration of lithium in blood preparations, methotrexate.

Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

Antacids and cholestyramine reduce the absorption.

Myelotoxic drugs increase the expression gematotoksichnosti drug.

 

 

Special instructions:

 

During treatment necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys.

If necessary, the definition of 17-keto steroids drug should be discontinued 48 hours prior to the study.

During treatment should refrain from activities potentially hazardous activities that require attention and speed of mental and motor responses. you should use the minimum effective dose as low as possible a short course to reduce the risk of adverse effects from the gastrointestinal tract. online anabolic steroids pharmacy

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